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Dynamic Expression of the BabA Adhesin and Its BabB

Membrane mucins cover the brush border membrane of enterocytes throughout the intestine, but their function remains undefined. Our aim is to elucidate the function of membrane mucins in intestinal barriers and to determine how we can harness the function of membrane mucins in order to combat diseases such as Inflammatory bowel disease (IBD) and endemic intestinal infections. Mucins are a family of high molecular weight, heavily glycosylated proteins produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers.

Mucin biology group

Mucins play a critical role in chronic lung disease, not only by providing a physical barrier and clearing pathogens, but also in immune homeostasis. The aim of this review is to familiarise the reader with the role of mucins in both lung health and disease, with particular focus on function in immunity, infection and inflammation. The mucin expands from the vesicle into this space at a very rapid rate. It is hypothesized that this rapid expansion is mediated by the exchange of sodium (and other monovalent cations) from the extracellular space with divalent calcium ions that are present in the vesicle in high concentration prior to exocytosis. All mucins are highly O-glycosylated by variable glycans depending on species, histoblood group and organ. This makes the intestinal main mucin MUC2 non-degradable by the host digestive system but A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.

GIARDIA INTESTINALIS - Dissertations.se

identified in colorectal carcinoma, including variations in blood group A, Lea, Leb, Department of Cell and Molecular Biology, Lund University; defense location av G Petrou · 2019 — The viscoelasticity of mucus is owing to mucins, a group of densely glycosylated mucus, mucin, protein adsorption, biomaterials, lubrication, olle.larko@outlook.com. Professor Gunnar C. Hansson, MD, PhD. Mucin Biology Groups, Dept. Medical Biochemistry, University of Gothenburg.

PDF CD4 + T cell-dependent airway mucus production

Here we provide databases of mucin genes, transcripts,protein sequences and functional domains. The databases are frompublished mucins and Mucins are a family of high molecular weight, heavily glycosylated proteins produced by epithelial tissues in most animals. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. They often take an inhibitory role. Some mucins are associated with controlling mineralization, including nacre formation in mollusks, calcification in echinoderms and bo Mucins are the major macromolecular components of mucus.

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Om. MUCIN and MUCUS in the GASTROINTESTINAL TRACT. Mer information. Research Team. Produkter. Mucin Biology Group, Göteborg.

Interaction of mucins with microflora plays an important role in normal function. There is growing recognition that mucus and mucin biology have a considerable impact on respiratory health, and subsequent global morbidity and mortality. Mucins play a critical role in chronic lung disease, not only by providing a physical barrier and clearing pathogens, but also in immune homeostasis.
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They often take an inhibitory role. Some mucins are associated with controlling mineralization, including nacre formation in mollusks, calcification in echinoderms and bo Mucins are a group of genes that transcribe for glycoproteins (MUC1-9) and that are differentially expressed in various tumor types. From: Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas, 2005. Download as PDF. There are two main groups of mucins; the classical gel-forming polymeric mucins (MUC2, MUC5AC, MUC5B, and MUC6) and a more heterogeneous group of monomeric transmembrane mucins (MUC1, MUC3, MUC4, MUC12, MUC13, MUC15, MUC16, MUC17, MUC20, and MUC21). Mucin biology is dynamic and the processes of degradation and turnover are well integrated with biosynthesis to maintain a continuous mucosal protection against all external aggressive forces.